Molecular Detection of the Macrolide Efflux Gene: To Discriminate or Not To Discriminate between mef (A) and mef (E)
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منابع مشابه
Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E).
The presence of a novel macrolide efflux system in streptococci was first described and firmly established in 1996 by Sutcliffe et al. (81). This system was phenotypically recognized and characterized to confer low-level resistance (MICs, 1 to 32 g/ml) to 14and 15-membered macrolides but not to 16membered macrolides, lincosamides, or streptogramin B (or their analogues). This phenotypic pattern...
متن کاملThree new macrolide efflux (mef) gene variants in Streptococcus agalactiae.
Streptococcus agalactiae (group B streptococcus [GBS]) is the most common cause of neonatal sepsis (9). Penicillin is used for intrapartum prophylaxis, but erythromycin or clindamycin is recommended for patients allergic to penicillin (3). There are two major mechanisms of erythromycin resistance in S. agalactiae, (i) erythromycin ribosomal methylase, mediated by ermB, ermA, ermTR, or ermC, whi...
متن کاملMacrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae.
Susceptibilities to macrolides were evaluated in 267 Streptococcus pneumoniae isolates, of which 182 were from patients with invasive diseases and 85 were from healthy carriers. Of the 98 resistant isolates, 20 strains showed an M phenotype and carried mef. Strains that carried both mef(A) and mef(E) were found: 17 strains carried mef(A) and 3 carried mef(E). The characteristics of the strains ...
متن کاملmef(A), mef(E) and a new mef allele in macrolide-resistant Streptococcus spp. isolates from Norway.
OBJECTIVES To type mef genes in a nationwide collection of clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes as well as pharyngeal carrier strains of viridans streptococci in Norway. METHODS Erythromycin-resistant mef-positive multilocus sequence-typed (MLST) clinical isolates of S. pneumoniae (n = 36) and S. pyogenes (n = 12) from the National Surveillance Program for ...
متن کاملCharacterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae.
The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2005
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.49.4.1271-1278.2005